Article
An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging.
PloS one - 1 Jan 2015
Vick Binje, Rothenberg Maja, Sandhöfer Nadine, Carlet Michela, Finkenzeller Cornelia, Krupka Christina, Grunert Michaela, Trumpp Andreas, Corbacioglu Selim, Ebinger Martin, André Maya C, Hiddemann Wolfgang, Schneider Stephanie, Subklewe Marion, Metzeler Klaus H, Spiekermann Karsten, Jeremias Irmela
Abstract excerpt
Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous disease with poor outcome. Adequate model systems are required for preclinical studies to improve understanding of AML biology and to develop novel, rational treatment approaches. Xenografts in immunodeficient mice allow performing functional studies on patient-derived AML cells. We have established an improved model system that integrates...
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