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Single-cell RNA sequencing reveals the impact of mechanical loading on knee tibial cartilage in osteoarthritis

14 Jan 2024

Abstract excerpt

Articular cartilage degeneration is one of the major pathogenic alterations observed in knee osteoarthritis (KOA). Mechanical stress has been verified to contribute to KOA development. To gain insight into the pathogenic mechanism of KOA development, we investigated chondrocyte subsets under different mechanical loading conditions via single-cell RNA sequencing (scRNA-seq). Articular cartilage tissues from both...

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PMID: 38224628
DOI: 10.1016/j.intimp.2024.111496

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