Article
Mechanical Induction of Osteoarthritis Traits in a Cartilage-on-a-Chip Model.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Mainardi Andrea, Occhetta Paola, Rasponi Marco
Abstract excerpt
The present lack of effective therapies for osteoarthritis, the most diffused musculoskeletal disease, correlates with the absence of representative in vitro disease models. Microfabrication techniques and soft lithography allow the development of organs and tissues on chip with increased mimicry of human pathophysiology. Exploitation of polydimethylsiloxane elasticity, furthermore, permits to incorporate finely...
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