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Article

Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications.

Bone research - 4 Feb 2024

Fan Xiwei, Sun Antonia Rujia, Young Reuben S E, Afara Isaac O, Hamilton Brett R, Ong Louis Jun Ye, Crawford Ross, Prasadam Indira

Abstract excerpt

Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, synovium, and adipose tissues. OA presents diverse clinical phenotypes and distinct molecular endotypes, including inflammatory, metabolic, mechanical, genetic, and synovial variants. Consequently, innovative technologies are needed to support the development of effective diagnostic and...

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Source

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Identifiers

PMID: 38311627
DOI: 10.1038/s41413-023-00304-6
PMCID: PMC10838951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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