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Article

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice.

Journal of molecular biology - 19 Jan 2018

Yu Chien-Hsiung, Moecking Jonas, Geyer Matthias, Masters Seth L

Abstract excerpt

NLRP1 was the first NOD-like receptor described to form an inflammasome, recruiting ASC to activate caspase-1, which processes interleukin-1β and interleukin-18 to their active form. A wealth of new genetic information has now redefined our understanding of this innate immune sensor. Specifically, rare loss-of-function variants in the N-terminal pyrin domain indicate that this part of NLRP1 is autoinhibitory and...

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Source

Identifiers

PMID: 28733143
DOI: 10.1016/j.jmb.2017.07.012

Genes

NLRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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