Article
Regulation of inflammasome activation.
Immunological reviews - 1 May 2015
Man Si Ming, Kanneganti Thirumala-Devi
Abstract excerpt
Inflammasome biology is one of the most exciting and rapidly growing areas in immunology. Over the past 10 years, inflammasomes have been recognized for their roles in the host defense against invading pathogens and in the development of cancer, auto-inflammatory, metabolic, and neurodegenerative diseases. Assembly of an inflammasome complex requires cytosolic sensing of pathogen-associated molecular patterns or...
Topics
- Animals
- Autoimmune Diseases
- Caspases
- Genetic Predisposition to Disease
- Humans
- Immunity
- Infections
- Inflammasomes
- Multiprotein Complexes
- Neoplasms
- Polymorphism, Genetic
- Protein Processing, Post-Translational