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Article

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.

Arthritis research & therapy - 12 Feb 2014

Ito Sayaka, Hara Yukichi, Kubota Tetsuo

Abstract excerpt

INTRODUCTION: NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and procaspase-1 to form a large protein complex termed inflammasome. Although some investigators have proposed a model of NLRP3-inflammasome containing an adaptor protein caspase...

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Topics

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Share to CARD Signaling Adaptor Proteins
Share to Cryopyrin-Associated Periodic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Immunoprecipitation

Share to Inflammasomes

Share to Leukocytes, Mononuclear

Share to Neoplasm Proteins

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24517500
DOI: 10.1186/ar4483
PMCID: PMC4060228

Genes

NLRP3
CARD8
CAPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.PMID 24517500Read ↗

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