Article

Co-inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer <i>via</i> readthrough transcription

2023-02-12

Abstract excerpt

Pancreatic carcinoma is one of the most lethal cancers and the absence of efficient therapeutic strategies results in poor prognosis. Transcriptional dysregulation due to alterations in KRAS and MYC impacts initiation, development, and survival of this tumor type. Using patient-derived xenografts of pancreatic carcinoma driven by KRAS and MYC oncogenic transcription, we show that co-inhibition of Topoisomerase 1 (...

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Literature Corpus work: 4af562f0-1b70-5eda-891a-51ed93140929
DOI: 10.1101/2023.02.10.527824

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