Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration.

Aging cell - 1 Jan 2022

Fathi Ali, Mathivanan Sakthikumar, Kong Linghai, Petersen Andrew J, Harder Cole R K, Block Jasper, Miller Julia Marie, Bhattacharyya Anita, Wang Daifeng, Zhang Su-Chun

Abstract excerpt

Modeling age-related neurodegenerative disorders with human stem cells are difficult due to the embryonic nature of stem cell-derived neurons. We developed a chemical cocktail to induce senescence of iPSC-derived neurons to address this challenge. We first screened small molecules that induce embryonic fibroblasts to exhibit features characteristic of aged fibroblasts. We then optimized a cocktail of small...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurodegenerative Diseases

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 34953016
DOI: 10.1111/acel.13541
PMCID: PMC8761019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration.PMID 34953016Read ↗

Chemically Induced Senescence in Human Stem Cell-Derived Neurons Promotes Phenotypic Presentation of NeurodegenerationSemantic proximity Read ↗

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegenerationSemantic proximity Read ↗

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain AgingSemantic proximity Read ↗

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation.Semantic proximity Read ↗

Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)Semantic proximity Read ↗

Alzheimer's disease in a dish: promises and challenges of human stem cell models.Semantic proximity Read ↗

Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.Semantic proximity Read ↗

Human-induced pluripotent stem cells: potential for neurodegenerative diseases.Semantic proximity Read ↗

iPSCs as a major opportunity to understand and cure age-related diseases.Semantic proximity Read ↗

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Semantic proximity Read ↗

A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegenerationSemantic proximity Read ↗

Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.