Article

Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2

2026-07-01

Abstract excerpt

Vaccination remains the most successful preventative measure against viral infection, but methods to stably deter rapidly-evolving pathogens have remained elusive. Vaccines capable of incorporating and anticipating viral evolution could address current challenges in seasonal vaccination efforts against SARS-CoV-2 and influenza where economic and disease burdens remain high despite decades of combined study. Rare e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4adb7dd7-8af6-5be6-9322-a799c164d86f
DOI: 10.64898/2026.07.01.735277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2DOI 10.64898/2026.07.01.735277Read

Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccineSemantic proximity Read

Engineering antigenic breadth against SARS-CoV-2 by pairing divergent RBDs within a single mRNA immunogenSemantic proximity Read

Computationally designed proteins mimic antibody immune evasion in viral evolutionSemantic proximity Read

Differential antibody dynamics to SARS-CoV-2 infection and vaccinationSemantic proximity Read

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralizationSemantic proximity Read

Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variantsSemantic proximity Read

Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity.Semantic proximity Read

Bivalent and Monovalent SARS-CoV-2 Variant Vaccine Boosters Improve coverage of the known Antigenic Landscape: Results of the COVID-19 Variant Immunologic Landscape (COVAIL) TrialSemantic proximity Read

Structure-guided design of a bivalent SARS-CoV-2 mRNA vaccine with NTD stabilizing mutations enhances broad immunity.Semantic proximity Read

Emerging Vaccine-Breakthrough SARS-CoV-2 VariantsSemantic proximity Read

Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine dosesSemantic proximity Read

Protein design for evaluating vaccines against future viral variationSemantic proximity Read