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Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants

9 Sept 2024

Abstract excerpt

Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 variants of concerns (VOCs). Here we describe three novel in-silico designed spike-based antigens capable of inducing neutralising antibodies across a spectrum of SARS-CoV-2 VOCs. Three sets of antigens utilising pre-Delta (T2_32), and post-Gamma sequence data (T2_35 and T2_36) were designed....

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PMID: 39251608
DOI: 10.1038/s41541-024-00950-9

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