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Article

Computationally designed proteins mimic antibody immune evasion in viral evolution

8 May 2025

Abstract excerpt

Recurrent waves of viral infection necessitate vaccines and therapeutics that remain effective against emerging viruses. Our ability to evaluate interventions is currently limited to assessments against past or circulating variants, which likely differ in their immune escape potential compared with future variants. To address this, we developed EVE-Vax, a computational method for designing antigens that...

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Identifiers

PMID: 40345199
DOI: 10.1016/j.immuni.2025.04.015

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