Article

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization

2026-06-04

Abstract excerpt

A central problem in achieving vaccine-based protection against viral infections is eliciting antibodies that are resilient to viral variation. Successive waves of SARS-CoV-2 infection during the COVID19 pandemic were driven by variants that acquired resistance to neutralizing antibodies elicited by prior SARS-CoV-2 variants. To the extent that serum neutralization breadth occurs in individuals with multiple expos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 261f35a6-ed5c-5fda-bc49-f34ab02f6d28
DOI: 10.64898/2026.06.03.729821

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralizationDOI 10.64898/2026.06.03.729821Read

Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies outside the receptor binding motifSemantic proximity Read

Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopesSemantic proximity Read

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2Semantic proximity Read

Design of SARS-CoV-2 RBD Immunogens to Focus Immune Responses Towards Conserved Coronavirus EpitopesSemantic proximity Read

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium studySemantic proximity Read

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprintingSemantic proximity Read

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktailsSemantic proximity Read

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccinationSemantic proximity Read

Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2Semantic proximity Read

Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variantsSemantic proximity Read

SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunitySemantic proximity Read

Incorporation of Sars-Cov-2 Spike Ntd to Rbd-Based Vaccine Improves Immunity and Protection Against Viral VariantsSemantic proximity Read