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Article

Structure-guided design of a bivalent SARS-CoV-2 mRNA vaccine with NTD stabilizing mutations enhances broad immunity.

Frontiers in immunology - 1 Jan 2025

Yeo Jinah, Yun Mi-Ran, Kim Seo-Yeon, Seok Jong-Hyun, Jeon Ji Hyang, Lee Taeyoung, Kim Jeonghun, Kim Kisoon, Park Man-Seong, Kim Dokeun, Kim You-Jin

Abstract excerpt

SARS-CoV-2 evolution, particularly the emergence of Omicron variants, has challenged vaccine efficacy, necessitating antigens with broad and variant-specific protection. To design mRNA vaccine antigens with broad-spectrum immunity and enhanced stability, we developed two spike antigens using in silico optimization: Css_dsg S, the ancestral strain-Delta variant consensus with stabilizing mutations, and Omi_dsg S,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41660617
DOI: 10.3389/fimmu.2025.1718740
PMCID: PMC12872526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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