Article

AAV-mediated gene therapy produces fertile offspring in the <i>Lhcgr</i> -deficient mouse model of Leydig cell failure

2021-04-07

Abstract excerpt

Leydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in restoring fertility. Here, we used a luteinizing hormone/choriogonadotrophin receptor ( Lhcgr )-deficient mouse model of genetic LCF to investigate the feasibility of gene therapy...

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Literature Corpus work: 4ad024ed-636d-51f8-9c07-5482d7177732
DOI: 10.1101/2021.04.07.438814

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AAV-mediated gene therapy produces fertile offspring in the <i>Lhcgr</i> -deficient mouse model of Leydig cell failureDOI 10.1101/2021.04.07.438814Read

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