Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiation of Human Induced Pluripotent Stem Cells Into Testosterone-Producing Leydig-like Cells

21 Sept 2021

Abstract excerpt

Late-onset hypogonadism (LOH) syndrome, due to a partial lack of testosterone, decreases the quality of life of older men. Testosterone is mainly secreted by Leydig cells in the testes. Leydig cell transplantation is expected to be a promising alternative to conventional testosterone replacement therapy for LOH syndrome. We herein report a simple and robust protocol for directed differentiation of human induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34549267
DOI: 10.1210/endocr/bqab202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differentiation of Human Induced Pluripotent Stem Cells Into Testosterone-Producing Leydig-like CellsPMID 34549267Read ↗

Efficient differentiation of human iPSCs into Leydig-like cells capable of long-term stable secretion of testosteroneSemantic proximity Read ↗

Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential ApplicationsSemantic proximity Read ↗

Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cellsSemantic proximity Read ↗

Establishment of a stem Leydig cell line capable of 11-ketotestosterone productionSemantic proximity Read ↗

Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells.Semantic proximity Read ↗

Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone productionSemantic proximity Read ↗

AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failureSemantic proximity Read ↗

Generation of human induced pluripotent stem cell (SKLRMi001-A) from a patient with partial androgen insensitivity syndrome (PAIS).Semantic proximity Read ↗

Stem Leydig cells: From fetal to aged animalsSemantic proximity Read ↗

AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failureSemantic proximity Read ↗

Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4Semantic proximity Read ↗

Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined FactorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.