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Article

Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.

Reproduction (Cambridge, England) - 1 Oct 2017

Penny Gervette M, Cochran Rebecca B, Pihlajoki Marjut, Kyrönlahti Antti, Schrade Anja, Häkkinen Merja, Toppari Jorma, Heikinheimo Markku, Wilson David B

Abstract excerpt

Testicular Leydig cells produce androgens essential for proper male reproductive development and fertility. Here, we describe a new Leydig cell ablation model based on Cre/Lox recombination of mouse Gata4 and Gata6, two genes implicated in the transcriptional regulation of steroidogenesis. The testicular interstitium of adult Gata4flox/flox ; Gata6flox/flox mice was injected with adenoviral vectors encoding...

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Identifiers

PMID: 28710293
DOI: 10.1530/REP-17-0311
PMCID: PMC5589507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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