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Article

Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis

24 Sept 2015

Abstract excerpt

Two distinct types of Leydig cells emerge during the development of eutherian mammals. Fetal Leydig cells (FLCs) appear shortly after gonadal sex differentiation, and play a crucial role in masculinization of male fetuses. Meanwhile, adult Leydig cells (ALCs) emerge after birth and induce the secondary male-specific sexual maturation by producing testosterone. Previous histological studies suggested that FLCs...

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PMID: 26402718
DOI: 10.1210/me.2015-1200

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