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Efficient differentiation of human iPSCs into Leydig-like cells capable of long-term stable secretion of testosterone

18 Jan 2025

Abstract excerpt

Late-onset hypogonadism (LOH) syndrome is characterized by age-related testosterone deficiency and negatively affects the quality of life of older men. A promising therapeutic approach for LOH syndrome is transplantation of testosterone-producing Leydig-like cells (LLCs) derived from human induced pluripotent stem cells (hiPSCs). However, previous studies have encountered obstacles, such as limited cell...

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PMID: 39824187
DOI: 10.1016/j.stemcr.2024.102392

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