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Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice

27 Apr 2022

Abstract excerpt

Oocytes and granulosa cells closely interact with each other during follicular development, and a lack of appropriate signaling between them results in infertility. Attempts to manipulate oocyte microenvironment have been impeded by the impermeability of the blood-follicle barrier (BFB). To establish a strategy for manipulating oogenesis, we use adeno-associated viruses (AAVs), which have a unique ability of...

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PMID: 35584625
DOI: 10.1016/j.xcrm.2022.100606

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