Article

AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure

2021-04-08

Abstract excerpt

<title>Abstract</title> <p>Leydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in restoring fertility. Here, we used a luteinizing hormone/choriogonadotrophin receptor (<italic>Lhcgr</italic>)-deficient mouse model of genetic LCF to in...

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Literature Corpus work: 104a87fd-b3a3-55f8-970b-ded78a2176b1
DOI: 10.21203/rs.3.rs-341691/v1

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AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failureDOI 10.21203/rs.3.rs-341691/v1Read

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