Article

Redundant γc cytokines license IL-1-driven neutrophil inflammation through MEK/ERK convergence

2026-06-01

Abstract excerpt

Interleukin-1 (IL-1) is a central driver of autoinflammatory disease, yet IL-1 blockade often provides incomplete benefit in complex, neutrophil-driven conditions. Here we identify a licensing circuit in which common γ-chain (γc) cytokines provide a redundant signal required for maximal IL-1–driven neutrophil inflammation. IL-1 and γc cytokines synergize to drive inflammatory cytokine production exceeding either s...

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Literature Corpus work: 4aa647b5-f2d6-5987-8f03-227441d08717
DOI: 10.64898/2026.05.28.728506

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