Article

Discrete cytokine signaling networks instruct distinct synovial pathotypes in inflammatory arthritis

2025-11-03

Abstract excerpt

Patients with rheumatoid arthritis (RA) display distinct patterns of synovitis. To define the inflammatory mechanisms driving this heterogeneity, we analyzed the inflamed synovium of wild-type (WT), Il6ra -/- , and Il27ra -/- mice with antigen-induced arthritis (AIA). Remarkably, each strain developed a joint pathology mirroring a major RA synovial pathotype: myeloid-rich (WT), fibroblast-rich/pauci-immune ( Il...

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Literature Corpus work: 5152d5d3-e7f7-5527-93a9-95b7b824a2cf
DOI: 10.1101/2025.11.01.686006

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