Article

Synovial fibroblast niche shapes the efficacy–safety dynamics of JAK inhibition in rheumatoid arthritis

2026-03-25

Abstract excerpt

Synovial fibroblasts (SF) drive joint pathology in rheumatoid arthritis (RA). Difficult-to-treat RA frequently exhibits a fibroblast-rich synovial pathotype, enriched in DKK3□ and CD34□ SF, highlighting a critical therapeutic gap. Through multicohort transcriptomic analysis of synovial tissues and mechanistic in vitro studies, we identified SF as principal targets of Janus kinase (JAK) inhibition in RA. We demons...

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Literature Corpus work: 617e0cf5-c316-5b1a-be6b-b46a448b0cb9
DOI: 10.64898/2026.03.23.713616

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