Article
CLN3, at the crossroads of endocytic trafficking.
Neuroscience letters - 25 Sept 2021
Cotman Susan L, Lefrancois Stéphane
Abstract excerpt
The CLN3 gene was identified over two decades ago, but the primary function of the CLN3 protein remains unknown. Recessive inheritance of loss of function mutations in CLN3 are responsible for juvenile neuronal ceroid lipofuscinosis (Batten disease, or CLN3 disease), a fatal childhood onset neurodegenerative disease causing vision loss, seizures, progressive dementia, motor function loss and premature death. CLN3...
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