Article
Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nature communications - 6 Aug 2024
Wan Yangzhuoqun, Guo Shuangshuang, Zhen Wenxuan, Xu Lizhen, Chen Xiaoying, Liu Fangyue, Shen Yi, Liu Shuangshuang, Hu Lidan, Wang Xinyan, Ye Fengcan, Wang Qinrui, Wen Han, Yang Fan
Abstract excerpt
The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical, as it is potentiated by ATP to detect metabolic energy level and point mutations in ClC-3 lead to severe neurodegenerative diseases in human. However, why this exchanger is differentially modulated by ATP, ADP or AMP and how mutations caused gain-of-function remains largely unknow. Here we determine the high-resolution...
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