Article

Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer’s disease- associations with Aβ, tau and synaptophysin

2025-01-22

Abstract excerpt

<h4>Background</h4> Synaptic dysfunction plays an important role in Alzheimer’s disease (AD) and is an emerging imaging and fluid biomarker. Here, we aimed to assess the regional expression of synaptic vesicle glycoprotein 2A (SV2A) in the brain and extracellular vesicles of AD patients and its associations with the APOE ε4 allele, amyloid-β, tau pathologies, and other synaptic markers. <h4>Methods</h4> Mass spe...

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Literature Corpus work: 4a93f337-e2ae-5ac7-9601-35b77e54c9c5
DOI: 10.1101/2025.01.21.634009

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