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Article

Evolution of antiviral resistance captures a transient interdomain functional interaction between chikungunya virus envelope glycoproteins.

mBio - 10 Dec 2025

Battini Leandro, Thannickal Sara A, Tejerina Cibello Malena, Bollini Mariela, Stapleford Kenneth A, Álvarez Diego E

Abstract excerpt

Envelope proteins drive virus and host-cell membrane fusion to achieve virus entry. Fusogenic proteins are classified into structural classes that function with remarkable mechanistic similarities. Membrane fusion implies coordinated movements of protein domains through a series of sequential steps. Structures for the initial and final conformations are available for several fusogens, but folding intermediates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41159720
DOI: 10.1128/mbio.02530-25
PMCID: PMC12691592

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