Article

Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion production

2021-06-22

Abstract excerpt

Alphaviruses and flaviviruses have class II fusion glycoproteins that are essential for virion assembly and infectivity. Importantly, the tip of domain II is structurally conserved between the alphavirus and flavivirus fusion proteins, yet whether these structural similarities between virus families translate to functional similarities is unclear. Using in vivo evolution of Zika virus (ZIKV), we identified severa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da7d7476-a659-5a0b-8074-cec6e6ffb932
DOI: 10.1101/2021.06.22.449399

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion productionDOI 10.1101/2021.06.22.449399Read

Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production.Semantic proximity Read

The La Crosse virus class II fusion glycoprotein <i>ij</i> loop contributes to infectivity and cholesterol-dependent entrySemantic proximity Read

Structures and Functions of the Envelope Glycoprotein in Flavivirus InfectionsSemantic proximity Read

Computational analysis of perturbations in the post-fusion Dengue virus envelope protein highlights known epitopes and conserved residues in the Zika virusSemantic proximity Read

The Evolving Role of Zika Virus Envelope Protein in Viral Entry and PathogenesisSemantic proximity Read

Mapping glycoprotein structure reveals Flaviviridae evolutionary historySemantic proximity Read

Pathogenesis and virulence of flavivirus infectionsSemantic proximity Read

Flavivirus: From Structure to Therapeutics DevelopmentSemantic proximity Read

Therapeutics for flaviviral infectionsSemantic proximity Read

Flavivirus-Mosquito InteractionsSemantic proximity Read

Flavivirus Receptors: Diversity, Identity, and Cell EntrySemantic proximity Read

Emerging chikungunya virus variants at the E1-E1 inter-glycoprotein spike interface impact virus attachment and InflammationSemantic proximity Read