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Article

Gata5 deficiency causes airway constrictor hyperresponsiveness in mice.

American journal of respiratory cell and molecular biology - 1 Apr 2014

Chen Bohao, Moore Tamson V, Li Zhenping, Sperling Anne I, Zhang Chunling, Andrade Jorge, Rodriguez Alex, Bahroos Neil, Huang Yong, Morrisey Edward E, Gruber Peter J, Solway Julian

Abstract excerpt

Gata5 is a transcription factor expressed in the lung, but its physiological role is unknown. To test whether and how Gata5 regulates airway constrictor responsiveness, we studied Gata5(-/-), Gata5(+/-), and wild-type mice on the C57BL/6J background. Cholinergic airway constrictor responsiveness was assessed invasively in mice without and with induction of allergic airway inflammation through ovalbumin...

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Identifiers

PMID: 24199649
DOI: 10.1165/rcmb.2013-0294OC
PMCID: PMC4068924

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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