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Article

Reversal of emphysema by restoration of pulmonary endothelial cells.

The Journal of experimental medicine - 2 Aug 2021

Hisata Shu, Racanelli Alexandra C, Kermani Pouneh, Schreiner Ryan, Houghton Sean, Palikuqi Brisa, Kunar Balvir, Zhou Aiyuan, McConn Keith, Capili Allyson, Redmond David, Nolan Daniel J, Ginsberg Michael, Ding Bi-Sen, Martinez Fernando J, Scandura Joseph M, Cloonan Suzanne M, Rafii Shahin, Choi Augustine M K

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction and eventual respiratory failure. Microvasculature dysfunction is associated with COPD/emphysema. However, it is not known if abnormal endothelium drives COPD/emphysema pathology and/or if correcting endothelial dysfunction has therapeutic potential. Here, we show the...

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Identifiers

PMID: 34287647
DOI: 10.1084/jem.20200938
PMCID: PMC8298104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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