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Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

1 Jun 2020

Abstract excerpt

Neurodegenerative diseases are a growing burden, and there is an urgent need for better biomarkers for diagnosis, prognosis, and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (CSF). Alzheimer's disease (AD) patients have higher CSF levels of tau, but we lack knowledge of systems-wide changes of CSF protein levels that accompany AD....

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PMID: 32485097
DOI: 10.15252/msb.20199356

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