Article
Human apolipoprotein E: the Alzheimer's disease connection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 1996
Weisgraber K H, Mahley R W
Abstract excerpt
Human apolipoprotein (apo) E, long known for its prominent role in cholesterol transport and plasma lipoprotein metabolism, has recently emerged as a major genetic risk factor for Alzheimer's disease, a neurodegenerative disorder. In a variety of populations worldwide, one of the three common alleles of apoE, apoE4, is overrepresented in Alzheimer's subjects compared with age- and sex-matched controls. The...
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