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Article

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.

Biochemistry - 27 Oct 2009

Fischer Daniela, Mukrasch Marco D, Biernat Jacek, Bibow Stefan, Blackledge Martin, Griesinger Christian, Mandelkow Eckhard, Zweckstetter Markus

Abstract excerpt

Aggregation of the microtubule-associated protein tau into neurofibrillary tangles is the pathological hallmark of a variety of dementias. For reasons not yet known, tau becomes excessively phosphorylated in Alzheimer's brains and as a result no longer binds properly to microtubules. Here we stud...

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Identifiers

PMID: 19769346
DOI: 10.1021/bi901090m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19769346-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.PMID 19769346Read ↗

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