Article

Crystalline silica exposure induces multiple systemic autoimmune phenotypes including inflammatory arthritis and nephritis in Collaborative Cross mice with differing sub-clinical autoimmune profiles

2025-05-27

Abstract excerpt

Inhalation of crystalline silica dust, an occupational hazard, has been strongly associated with the development of autoimmune connective tissue diseases, such as rheumatoid arthritis and systemic lupus erythematosus. However, it remains unclear if silica-mediated autoimmune disease requires preexisting subclinical autoimmunity, and to what extent the severity of the preexisting condition influences silica-induced...

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Literature Corpus work: 4a1b2441-d352-53b2-a98d-8daa3c4aa1fb
DOI: 10.1101/2025.05.22.655650

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