Potential causal relationships between metabolites, immunophenotypes, and uveitis disease: A Mediation Mendelian Randomization Study

Abstract excerpt

<h4>Background: </h4> There is substantial evidence that immune cells play a role in the pathogenesis of uveitis. Establishing causal relationships is challenging due to confounding biasing mechanisms of reverse causation and residual relationships. <h4>Methods: </h4> Instrumental variables for 731 immune phenotypes, 1091 blood metabolites, and 309 metabolite ratios were derived from genome-wide association studi...

Topics

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• Cytokines
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Glomerulonephritis, IGA
• Immunophenotyping
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Uveitis

Identifiers and source

Literature Corpus work

4a1557e4-4a23-5f67-8d7f-eab4b13aa870

DOI

10.21203/rs.3.rs-3987206/v1