Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases.

Arthritis research & therapy - 2 Dec 2024

Wei Jinpeng, Li Jian, Li Tianyang, Xu Tao, Zhang Yingchi, Yang Shuhan, Wu Hua, Hao Haihu

Abstract excerpt

BACKGROUND: This study investigates the causal role of metabolites mediating immune cells in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) through a Mendelian randomization (MR) study. METHODS: The two-sample and two-step MR methods were used for the current analysis: (1) causal effects of immune cells on RA and AS; (2) mediation effects of metabolites. Inverse variance weighted (IVW) is the main...

Topics

Join the communities discussing this publication.

Arthritis, Rheumatoid
Autoimmune Diseases
Genetic Predisposition to Disease
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spondylitis, Ankylosing

Source

Open in PubMed Open full text

Identifiers

PMID: 39623398
DOI: 10.1186/s13075-024-03445-z
PMCID: PMC11610274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases.PMID 39623398Read ↗

Causal association between plasma metabolites and diverse autoimmune diseases: a two-sample bidirectional mendelian randomization study.Semantic proximity Read ↗

Role of metabolites in mediating the effect of lipidomes on rheumatoid arthritisSemantic proximity Read ↗

Identifying serum metabolite biomarkers for autoimmune diseases: a two-sample mendelian randomization and meta-analysisSemantic proximity Read ↗

Identification of causal metabolites related to multiple autoimmune diseases.Semantic proximity Read ↗

Uncovering metabolite-immune interactions in the pathogenesis of psoriatic arthritis: A 2-sample Mendelian randomization study.Semantic proximity Read ↗

Genetically predicted associations between circulating cytokines and autoimmune diseases: a bidirectional two-sample Mendelian randomization.Semantic proximity Read ↗

Effects of Immune Cells and Plasma Metabolites on Osteoarthritis: A Mediation Mendelian Randomization Study.Semantic proximity Read ↗

Causality of genetically determined metabolites and metabolic pathways on joint diseases: a two-sample mendelian randomization studySemantic proximity Read ↗

Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells.Semantic proximity Read ↗

The Causal Relationship Between Genetically Determined Plasma Metabolites and Rheumatoid Arthritis.Semantic proximity Read ↗

Circulating metabolites mediating the effect of psoriatic arthritis on Crohn disease risk: A mediation Mendelian randomization study.Semantic proximity Read ↗

Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.