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Article

Exploring the causal effect of complement and IgA nephropathy-a Mendelian randomization study.

Renal failure - 1 Dec 2024

Xu Han, Zou Mengxiao, Cheng Yichun, Ge Shuwang

Abstract excerpt

IgA nephropathy, one of the most common primary glomerulonephritis worldwide, is still under investigation for its precise etiology. The widely accepted theory is the 'four-hit model' and subsequent complement and inflammatory responses. Recent studies have reported correlations between specific complement components and IgA nephropathy. However, the causal effects of genetically predicted complement components...

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Share to Complement System Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulonephritis, IGA

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 39627156
DOI: 10.1080/0886022X.2024.2436632
PMCID: PMC11616755

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