Article
Genome-wide analysis of histone modifications in human pancreatic islets.
Genome research - 1 Apr 2010
Bhandare Reena, Schug Jonathan, Le Lay John, Fox Alan, Smirnova Olga, Liu Chengyang, Naji Ali, Kaestner Klaus H
Abstract excerpt
The global diabetes epidemic poses a major challenge. Epigenetic events contribute to the etiology of diabetes; however, the lack of epigenomic analysis has limited the elucidation of the mechanistic basis for this link. To determine the epigenetic architecture of human pancreatic islets we mapped the genome-wide locations of four histone marks: three associated with gene activation-H3K4me1, H3K4me2, and...
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