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NRF2 pathway activation reverts high-glucose-induced transcriptional memory in endothelial cells

2023-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Various diabetes complications, including nephropathy, retinopathy, and cardiovascular disease, arise from vascular dysfunction. In this context, it has been observed that past hyperglycaemic events can induce long-lasting transcriptional changes, a phenomenon termed “metabolic memory”. Yet, the underlying mechanisms driving these persistent effects are not fully characterized. In this study, we...

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Literature Corpus work
49ea7652-e38d-52f1-a70b-c5fe031c99c7
DOI
10.1101/2023.09.11.557207
Open publication

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NRF2 pathway activation reverts high-glucose-induced transcriptional memory in endothelial cellsDOI 10.1101/2023.09.11.557207
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