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Article

Epigenetic Modifications of Keap1 Regulate Its Interaction With the Protective Factor Nrf2 in the Development of Diabetic Retinopathy

10 Oct 2014

Abstract excerpt

PURPOSE: Diabetes induces oxidative imbalance in the retina and impairs Nrf2-mediated antioxidant response, and elevates Keap1, the cytoplasmic repressor of Nrf2. The goal of this study was to understand the role of epigenetic modifications at Keap1 promoter in regulation of Nrf2 function. METHODS: The effect of high glucose on the binding of transcriptional factor Sp1 at Keap1 promoter and histone methylation...

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PMID: 25301875
DOI: 10.1167/iovs.14-15193

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