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Mechanical differences of sickle cell trait (SCT) and normal red blood cells

1 Jan 2015

Abstract excerpt

Sickle cell trait (SCT) is a condition in which an individual inherits one sickle hemoglobin gene (HbS) and one normal beta hemoglobin gene (HbA). It has been hypothesized that under extreme physical stress, the compromised mechanical properties of the red blood cells (RBCs) may be the underlying mechanism of clinical complications of sickle cell trait individuals. However, whether sickle cell trait (SCT) should...

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PMID: 26066022
DOI: 10.1039/c5lc00543d

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