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Hemoglobin C is prone to oxidative denaturation, resulting in red blood cell membrane damage in HbSC disease

2026-06-10

Abstract excerpt

Sickle-hemoglobin-C (HbSC) sickle cell disease is characterized by RBC dehydration (xerocytosis), which promotes polymerization of HbS. HbSC causes substantial morbidity despite lower sickling potential than HbSS, suggesting a critical detrimental role of HbC in the disease pathophysiology. We derived HbCC mice by interbreeding our HbSC mice, which demonstrated a similar RBC phenotype of xerocytosis as humans with...

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Literature Corpus work
01efbf07-9fdf-5a0c-bb65-15d92aa6618e
DOI
10.64898/2026.06.05.729662
Open publication

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