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Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level

1 Feb 2023

Abstract excerpt

INTRODUCTION: In sickle cell disease (SCD), a single amino acid substitution at β6 of the hemoglobin (Hb) chain replaces glutamate with valine, forming HbS instead of the normal adult HbA. Loss of a negative charge, and the conformational change in deoxygenated HbS molecules, enables formation of HbS polymers. These not only distort red cell morphology but also have other profound effects so that this simple...

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PMID: 36803179
DOI: 10.1080/14728222.2023.2179484

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