The DiffInvex evolutionary model for conditional somatic selection identifies chemotherapy resistance genes in 10,000 cancer genomes

Abstract excerpt

Tumors often show an initial response to chemotherapy, but then develop resistance, leading to relapse and poor prognosis. We hypothesized that a genomic comparison of mutations in pre-treated versus treatment-naive tumors would serve to identify genes that confer resistance. A challenge in such an analysis is that therapy alters mutation burdens and signatures, confounding association studies and complicating ide...

Topics

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• INDEL Mutation
• Microsatellite Instability
• Models, Genetic
• Mutation Rate
• Neoplasms
• Point Mutation
• Polymorphism, Single Nucleotide
• Selection, Genetic

Identifiers and source

Literature Corpus work

49ddbbc2-e85f-5ac7-82ce-9dec50917e77

DOI

10.1101/2024.06.17.599362