Detecting context-dependent selection on cancer driver genes with DiffDriver

Abstract excerpt

Positive selection on somatic mutations is the driving force for cancer progression. Growing evidence shows that the emergence of a driver mutation in a tumor sample depends on individual-specific factors, for example environmental exposures or the individual’s germline genetic background. We term these individual-level factors as the “contexts” of a tumor. Our hypothesis is that mutations in a driver gene can bri...

Topics

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• INDEL Mutation
• Microsatellite Instability
• Models, Genetic
• Mutation Rate
• Neoplasms
• Point Mutation
• Polymorphism, Single Nucleotide
• Selection, Genetic

Identifiers and source

Literature Corpus work

9da85d77-6c8e-5f67-9d57-e7e8e5c588f9

DOI

10.64898/2026.04.06.716771