Article
Pharmacological enrichment of polygenic risk for precision medicine in complex disorders
2019-06-03
Abstract excerpt
<h4>ABSTRACT</h4> Individuals with complex disorders typically have a heritable burden of common variation that can be expressed as a polygenic risk score (PRS). While PRS has some predictive utility, it lacks the molecular specificity to be directly informative for clinical interventions. We therefore sought to develop a framework to quantify an individual’s common variant enrichment in clinically actionable sys...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 3536e65f-3e96-5570-8df4-05a3fb8a79aa
- DOI
- 10.1101/655001