Article

Convergent coexpression reveals shared biological mechanisms underlying common and rare variant risk in six neuropsychiatric disorders

2025-08-15

Abstract excerpt

Genome-wide association studies (GWAS) and large-scale rare variant burden analyses have identified both common and rare loss-of-function variants associated with neuropsychiatric disorders. Yet, the shared biological processes influenced by both classes of variation remain poorly characterized. In this study, we utilized transcriptomic data from 933 post-mortem brain samples to identify genes that show convergent...

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Literature Corpus work: e53991aa-4ab6-554b-a114-12db25b52585
DOI: 10.1101/2025.08.13.25333593

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