Article

Convergent and non-additive impact of schizophrenia risk genes in human neurons

2022-03-30

Abstract excerpt

<h4>ABSTRACT</h4> Genetic studies of schizophrenia reveal a complex polygenic risk architecture comprised of hundreds of risk variants; most are common in the population at-large, non-coding, and act by genetically regulating the expression of one or more gene targets (“eGenes”). It remains unclear how genetic variants predicted to confer individually small effects combine to yield substantial clinical impacts in...

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Literature Corpus work: 0abe3007-996f-5c58-81e7-6ca71c4282a1
DOI: 10.1101/2022.03.29.486286

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