Article
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor.
Cell - 2 Mar 2012
Xu Xun, Hou Yong, Yin Xuyang, Bao Li, Tang Aifa, Song Luting, Li Fuqiang, Tsang Shirley, Wu Kui, Wu Hanjie, He Weiming, Zeng Liang, Xing Manjie, Wu Renhua, Jiang Hui, Liu Xiao, Cao Dandan, Guo Guangwu, Hu Xueda, Gui Yaoting, Li Zesong, Xie Wenyue, Sun Xiaojuan, Shi Min, Cai Zhiming, Wang Bin, Zhong Meiming, Li Jingxiang, Lu Zuhong, Gu Ning, Zhang Xiuqing, Goodman Laurie, Bolund Lars, Wang Jian, Yang Huanming, Kristiansen Karsten, Dean Michael, Li Yingrui, Wang Jun
Abstract excerpt
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer and has very few mutations that are shared between different patients. To better understand the intratumoral genetics underlying mutations of ccRCC, we carried out single-cell exome sequencing on a ccRCC tumor and its adjacent kidney tissue. Our data indicate that this tumor was unlikely to have resulted from mutations in VHL and PBRM1....
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